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As Latin America and the Caribbean continues to battle with the COVID-19 pandemic and its socioeconomic costs, illicit trade markets are thriving and re-shaping supply chains. Illicit trade puts consumer safety at risk, affects government revenue and its ability to provide services, and erodes the business environment. How has the pandemic affected illicit trade flows across the region? What best practices can Latin America and the Caribbean offer on combatting illicit trade and what are lessons from other regions? How can governments, the private sector and civil society work together to reduce illicit trade?